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Thirty-six hemodiluted and 30 control patients survived the first year following the stroke(difference not significant).One year after the stroke,persistent neurological deficits were less frequent among the hemodiluted patients and a larger proportion of hemodiluted survivors was independent in walking(92%versus 73%,p<0.05).Two hemodiluted patients(6%) and nine control patients(30%)were totally dependent in the activities of daily living(p<0.05).Three hemodiluted patients(8%)and eight control patients(27%)remained hospitalized 1 year after the stroke(p<0.05).With the possible exception of patients with a medical history of congestive heart failure,subset analyses revealed a tendency toward improved outcome for hemodiluted patients in all clinically important subgroups compared with the controls.When analyzing cerebrospinal fluid,signs of blood-brain barrier breakdown and hemorrhagic admixture to the cerebrospinal fluid during the acute phase were less frequent in the hemodiluted subjects. Conclusions:These results suggest that,when applied in a stroke unit,the combination of venesection and dextran 40 administration is a clinically safe,therapeutic regimen in the treatment of acute cerebral infarction that improves long-term clinical outcome. |
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activities of daily living
activities of daily living scale
cerebral ischemia
cerebrovascular accident
cerebrovascular accident,acute management of
cerebrovascular accident,prognosis in
dextran
disability,neurological
hemodilution
treatment of neurologic disorder
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